Periodical Antibiotic Treatment for the Control of Gonococcal and Chlamydial Infections Among Sex Workers in Benin and Ghana: A Cluster-Randomized Placebo-Controlled Trial
Identifieur interne : 000790 ( Main/Exploration ); précédent : 000789; suivant : 000791Periodical Antibiotic Treatment for the Control of Gonococcal and Chlamydial Infections Among Sex Workers in Benin and Ghana: A Cluster-Randomized Placebo-Controlled Trial
Auteurs : Annie-Claude Labbe [Canada] ; Jacques Pepin [Canada] ; Nzambi Khonde [Ghana] ; Agnes Dzokoto [Ghana] ; Honoré Meda [Bénin] ; Comfort Asamoah-Adu [Ghana] ; Philippe Mayaud [Royaume-Uni] ; David Mabey [Royaume-Uni] ; Eric Demers [Canada] ; Michel Alary [Canada]Source :
- Sexually transmitted diseases [ 0148-5717 ] ; 2012.
Descripteurs français
- Pascal (Inist)
- Wicri :
- geographic : Bénin, Ghana.
- topic : Maladie sexuellement transmissible, Antibiotique, Prostitution.
English descriptors
- KwdEn :
Abstract
Background: In resource-poor settings, control of Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) among female sex workers (FSWs) is difficult. We sought to determine whether periodical antibiotic treatment (PAT) might be effective in controlling these infections among West African FSWs. Secondary objectives were to determine the impact of PAT on human immunodeficiency virus (HIV) incidence among FSWs and on NG/CT prevalence among their clients. Methods: Cluster-randomized, double-blind, placebo-controlled trial among FSW communities in Benin and Ghana. Within each of 9 pairs of clusters of FSW communities, one was allocated to receive, during 9 months, a monthly antibiotic (alternatively ciprofloxacin or azithromycin, n = 296 FSWs) and the other a placebo (n = 340 FSWs). Prevalence of NG/CT infections was measured at 3-month intervals using the polymerase chain reaction. HIV status was determined at the beginning and at the end of the study. Results: After adjusting for age, HIV status, duration of prostitution, price per intercourse and condom use, and accounting for prevalence at enrollment and cluster-pairing effect, prevalence ratios (intervention vs. placebo) of NG infection were 0.77 (P = NS), 1.07 (P = NS), and 0.49 (P = 0.05) at the first, second, and third follow-up visits, respectively. PAT neither reduced significantly CT prevalence or HIV incidence among FSWs nor NG/CT prevalence among their clients. Conclusion: The only beneficial impact of PAT was on the prevalence of gonococcal infections among FSWs 9 months after the beginning of the intervention. Although PAT could be more effective in other circumstances, for instance, in the early stages of a program for FSWs, it can not be recommended at present as a routine strategy to control cervical infections among FSWs.
Affiliations:
- Bénin, Canada, Ghana, Royaume-Uni
- Angleterre, Grand Londres, Québec, Région du Grand Accra
- Accra, Londres, Montréal
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000020
- to stream PascalFrancis, to step Curation: 000109
- to stream PascalFrancis, to step Checkpoint: 000016
- to stream Main, to step Merge: 000791
- to stream Main, to step Curation: 000790
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Periodical Antibiotic Treatment for the Control of Gonococcal and Chlamydial Infections Among Sex Workers in Benin and Ghana: A Cluster-Randomized Placebo-Controlled Trial</title><author><name sortKey="Labbe, Annie Claude" sort="Labbe, Annie Claude" uniqKey="Labbe A" first="Annie-Claude" last="Labbe">Annie-Claude Labbe</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Microbiology, Hôpital Maisonneuve-Rosemont</s1><s2>Montreal</s2><s3>CAN</s3><sZ>1 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Pepin, Jacques" sort="Pepin, Jacques" uniqKey="Pepin J" first="Jacques" last="Pepin">Jacques Pepin</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Microbiology and Infectious Diseases, Université de Sherbrooke</s1><s2>Sherbrooke</s2><s3>CAN</s3><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Sherbrooke</wicri:noRegion></affiliation></author><author><name sortKey="Khonde, Nzambi" sort="Khonde, Nzambi" uniqKey="Khonde N" first="Nzambi" last="Khonde">Nzambi Khonde</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>West Africa Project to Combat AIDS</s1><s2>Accra</s2><s3>GHA</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Ghana</country><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName></affiliation></author><author><name sortKey="Dzokoto, Agnes" sort="Dzokoto, Agnes" uniqKey="Dzokoto A" first="Agnes" last="Dzokoto">Agnes Dzokoto</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Ministry of Health, Greater Accra Region</s1><s2>Accra</s2><s3>GHA</s3><sZ>4 aut.</sZ></inist:fA14><country>Ghana</country><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName></affiliation></author><author><name sortKey="Meda, Honore" sort="Meda, Honore" uniqKey="Meda H" first="Honoré" last="Meda">Honoré Meda</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Projet SIDA3-Bénin</s1><s2>Cotonou</s2><s3>BEN</s3><sZ>5 aut.</sZ></inist:fA14><country>Bénin</country><wicri:noRegion>Projet SIDA3-Bénin</wicri:noRegion></affiliation></author><author><name sortKey="Asamoah Adu, Comfort" sort="Asamoah Adu, Comfort" uniqKey="Asamoah Adu C" first="Comfort" last="Asamoah-Adu">Comfort Asamoah-Adu</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>West Africa Project to Combat AIDS</s1><s2>Accra</s2><s3>GHA</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Ghana</country><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName></affiliation></author><author><name sortKey="Mayaud, Philippe" sort="Mayaud, Philippe" uniqKey="Mayaud P" first="Philippe" last="Mayaud">Philippe Mayaud</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Clinical Research Department, Faculty of Infectious & Tropical Diseases, London School of Hygiene and Tropical Medicine</s1><s2>London</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Mabey, David" sort="Mabey, David" uniqKey="Mabey D" first="David" last="Mabey">David Mabey</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Clinical Research Department, Faculty of Infectious & Tropical Diseases, London School of Hygiene and Tropical Medicine</s1><s2>London</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Demers, Eric" sort="Demers, Eric" uniqKey="Demers E" first="Eric" last="Demers">Eric Demers</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Unité de recherche en santé des populations, Centre de recherche FRSQ du CHA universitaire de Quebec</s1><s3>CAN</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Unité de recherche en santé des populations, Centre de recherche FRSQ du CHA universitaire de Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Alary, Michel" sort="Alary, Michel" uniqKey="Alary M" first="Michel" last="Alary">Michel Alary</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Unité de recherche en santé des populations, Centre de recherche FRSQ du CHA universitaire de Quebec</s1><s3>CAN</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Unité de recherche en santé des populations, Centre de recherche FRSQ du CHA universitaire de Quebec</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Départment de médecine sociale et préventive, Université Laval</s1><s2>Québec</s2><s3>CAN</s3><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Québec</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0165668</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0165668 INIST</idno><idno type="RBID">Pascal:12-0165668</idno><idno type="wicri:Area/PascalFrancis/Corpus">000020</idno><idno type="wicri:Area/PascalFrancis/Curation">000109</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000016</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000016</idno><idno type="wicri:doubleKey">0148-5717:2012:Labbe A:periodical:antibiotic:treatment</idno><idno type="wicri:Area/Main/Merge">000791</idno><idno type="wicri:Area/Main/Curation">000790</idno><idno type="wicri:Area/Main/Exploration">000790</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Periodical Antibiotic Treatment for the Control of Gonococcal and Chlamydial Infections Among Sex Workers in Benin and Ghana: A Cluster-Randomized Placebo-Controlled Trial</title><author><name sortKey="Labbe, Annie Claude" sort="Labbe, Annie Claude" uniqKey="Labbe A" first="Annie-Claude" last="Labbe">Annie-Claude Labbe</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Microbiology, Hôpital Maisonneuve-Rosemont</s1><s2>Montreal</s2><s3>CAN</s3><sZ>1 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Pepin, Jacques" sort="Pepin, Jacques" uniqKey="Pepin J" first="Jacques" last="Pepin">Jacques Pepin</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Microbiology and Infectious Diseases, Université de Sherbrooke</s1><s2>Sherbrooke</s2><s3>CAN</s3><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Sherbrooke</wicri:noRegion></affiliation></author><author><name sortKey="Khonde, Nzambi" sort="Khonde, Nzambi" uniqKey="Khonde N" first="Nzambi" last="Khonde">Nzambi Khonde</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>West Africa Project to Combat AIDS</s1><s2>Accra</s2><s3>GHA</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Ghana</country><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName></affiliation></author><author><name sortKey="Dzokoto, Agnes" sort="Dzokoto, Agnes" uniqKey="Dzokoto A" first="Agnes" last="Dzokoto">Agnes Dzokoto</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Ministry of Health, Greater Accra Region</s1><s2>Accra</s2><s3>GHA</s3><sZ>4 aut.</sZ></inist:fA14><country>Ghana</country><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName></affiliation></author><author><name sortKey="Meda, Honore" sort="Meda, Honore" uniqKey="Meda H" first="Honoré" last="Meda">Honoré Meda</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Projet SIDA3-Bénin</s1><s2>Cotonou</s2><s3>BEN</s3><sZ>5 aut.</sZ></inist:fA14><country>Bénin</country><wicri:noRegion>Projet SIDA3-Bénin</wicri:noRegion></affiliation></author><author><name sortKey="Asamoah Adu, Comfort" sort="Asamoah Adu, Comfort" uniqKey="Asamoah Adu C" first="Comfort" last="Asamoah-Adu">Comfort Asamoah-Adu</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>West Africa Project to Combat AIDS</s1><s2>Accra</s2><s3>GHA</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Ghana</country><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName></affiliation></author><author><name sortKey="Mayaud, Philippe" sort="Mayaud, Philippe" uniqKey="Mayaud P" first="Philippe" last="Mayaud">Philippe Mayaud</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Clinical Research Department, Faculty of Infectious & Tropical Diseases, London School of Hygiene and Tropical Medicine</s1><s2>London</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Mabey, David" sort="Mabey, David" uniqKey="Mabey D" first="David" last="Mabey">David Mabey</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Clinical Research Department, Faculty of Infectious & Tropical Diseases, London School of Hygiene and Tropical Medicine</s1><s2>London</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Demers, Eric" sort="Demers, Eric" uniqKey="Demers E" first="Eric" last="Demers">Eric Demers</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Unité de recherche en santé des populations, Centre de recherche FRSQ du CHA universitaire de Quebec</s1><s3>CAN</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Unité de recherche en santé des populations, Centre de recherche FRSQ du CHA universitaire de Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Alary, Michel" sort="Alary, Michel" uniqKey="Alary M" first="Michel" last="Alary">Michel Alary</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Unité de recherche en santé des populations, Centre de recherche FRSQ du CHA universitaire de Quebec</s1><s3>CAN</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Unité de recherche en santé des populations, Centre de recherche FRSQ du CHA universitaire de Quebec</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Départment de médecine sociale et préventive, Université Laval</s1><s2>Québec</s2><s3>CAN</s3><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Québec</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Sexually transmitted diseases</title><title level="j" type="abbreviated">Sex. transm. dis.</title><idno type="ISSN">0148-5717</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Sexually transmitted diseases</title><title level="j" type="abbreviated">Sex. transm. dis.</title><idno type="ISSN">0148-5717</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibacterial agent</term><term>Antibiotic</term><term>Benin</term><term>Check</term><term>Chlamydiosis</term><term>Ghana</term><term>Gonococcal infection</term><term>Prostitution</term><term>Sexually transmitted disease</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Gonococcie</term><term>Maladie sexuellement transmissible</term><term>Antibactérien</term><term>Antibiotique</term><term>Traitement</term><term>Contrôle</term><term>Chlamydiose</term><term>Prostitution</term><term>Bénin</term><term>Ghana</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Bénin</term><term>Ghana</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Maladie sexuellement transmissible</term><term>Antibiotique</term><term>Prostitution</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: In resource-poor settings, control of Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) among female sex workers (FSWs) is difficult. We sought to determine whether periodical antibiotic treatment (PAT) might be effective in controlling these infections among West African FSWs. Secondary objectives were to determine the impact of PAT on human immunodeficiency virus (HIV) incidence among FSWs and on NG/CT prevalence among their clients. Methods: Cluster-randomized, double-blind, placebo-controlled trial among FSW communities in Benin and Ghana. Within each of 9 pairs of clusters of FSW communities, one was allocated to receive, during 9 months, a monthly antibiotic (alternatively ciprofloxacin or azithromycin, n = 296 FSWs) and the other a placebo (n = 340 FSWs). Prevalence of NG/CT infections was measured at 3-month intervals using the polymerase chain reaction. HIV status was determined at the beginning and at the end of the study. Results: After adjusting for age, HIV status, duration of prostitution, price per intercourse and condom use, and accounting for prevalence at enrollment and cluster-pairing effect, prevalence ratios (intervention vs. placebo) of NG infection were 0.77 (P = NS), 1.07 (P = NS), and 0.49 (P = 0.05) at the first, second, and third follow-up visits, respectively. PAT neither reduced significantly CT prevalence or HIV incidence among FSWs nor NG/CT prevalence among their clients. Conclusion: The only beneficial impact of PAT was on the prevalence of gonococcal infections among FSWs 9 months after the beginning of the intervention. Although PAT could be more effective in other circumstances, for instance, in the early stages of a program for FSWs, it can not be recommended at present as a routine strategy to control cervical infections among FSWs.</div></front></TEI><affiliations><list><country><li>Bénin</li><li>Canada</li><li>Ghana</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Québec</li><li>Région du Grand Accra</li></region><settlement><li>Accra</li><li>Londres</li><li>Montréal</li></settlement></list><tree><country name="Canada"><region name="Québec"><name sortKey="Labbe, Annie Claude" sort="Labbe, Annie Claude" uniqKey="Labbe A" first="Annie-Claude" last="Labbe">Annie-Claude Labbe</name></region><name sortKey="Alary, Michel" sort="Alary, Michel" uniqKey="Alary M" first="Michel" last="Alary">Michel Alary</name><name sortKey="Alary, Michel" sort="Alary, Michel" uniqKey="Alary M" first="Michel" last="Alary">Michel Alary</name><name sortKey="Demers, Eric" sort="Demers, Eric" uniqKey="Demers E" first="Eric" last="Demers">Eric Demers</name><name sortKey="Pepin, Jacques" sort="Pepin, Jacques" uniqKey="Pepin J" first="Jacques" last="Pepin">Jacques Pepin</name></country><country name="Ghana"><region name="Région du Grand Accra"><name sortKey="Khonde, Nzambi" sort="Khonde, Nzambi" uniqKey="Khonde N" first="Nzambi" last="Khonde">Nzambi Khonde</name></region><name sortKey="Asamoah Adu, Comfort" sort="Asamoah Adu, Comfort" uniqKey="Asamoah Adu C" first="Comfort" last="Asamoah-Adu">Comfort Asamoah-Adu</name><name sortKey="Dzokoto, Agnes" sort="Dzokoto, Agnes" uniqKey="Dzokoto A" first="Agnes" last="Dzokoto">Agnes Dzokoto</name></country><country name="Bénin"><noRegion><name sortKey="Meda, Honore" sort="Meda, Honore" uniqKey="Meda H" first="Honoré" last="Meda">Honoré Meda</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Mayaud, Philippe" sort="Mayaud, Philippe" uniqKey="Mayaud P" first="Philippe" last="Mayaud">Philippe Mayaud</name></region><name sortKey="Mabey, David" sort="Mabey, David" uniqKey="Mabey D" first="David" last="Mabey">David Mabey</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaGhanaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000790 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000790 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= SidaGhanaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:12-0165668
|texte= Periodical Antibiotic Treatment for the Control of Gonococcal and Chlamydial Infections Among Sex Workers in Benin and Ghana: A Cluster-Randomized Placebo-Controlled Trial
}}
| This area was generated with Dilib version V0.6.31. |  |